Category: RNA
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![moRNA, circRNA, snRNA [How many types of ncRNA do you know? Ep. 4/7]](https://writingenomics.com/wp-content/uploads/2025/09/ep-4.png?w=1024)
moRNA, circRNA, snRNA [How many types of ncRNA do you know? Ep. 4/7]
This week, our journey in the ncRNAs universe brings us back to miRNAs before moving to splicing and the RNAs that make it possible. Let’s get going fellow travellers! 10. microRNA-offset RNA (moRNA) These ~ 20 nt long transcripts are coded in the regions of the pri-miRNA directly flanking the pre-miRNA. They were initially considered…
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Treating Huntington’s Disease and Beyond: Three Applications of miRNAs in Gene Therapy
A microRNA (miRNA) is on the news since Wednesday; many just haven’t been told. I am referring to AMT-130 by UniQure, the gene therapy slowing the progression of Huntington’s disease [1]. In a nutshell, the miRNA in AMT-130 reduces the level of the protein huntingtin in neurons, which a mutation has turned toxic in Huntington…
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![miRNA, endo-siRNA, piRNA [How many types of ncRNA do you know?Ep. 3/7]](https://writingenomics.com/wp-content/uploads/2025/09/ep3-mirna-sirna-pirna.png?w=1024)
miRNA, endo-siRNA, piRNA [How many types of ncRNA do you know?Ep. 3/7]
This week, our journey in the ncRNAs universe explore the two players of the RNA interference (RNAi) pathway, and their close relative. Let’s get going fellow travellers! 7. microRNA (miRNA) They are ~22 nt long, and play a central role in regulating gene expression. This group of small regulatory RNAs is part of the RNAi…
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![snoRNA, sdRNA, scaRNA [How many types of ncRNA do you know? Ep. 2/7]](https://writingenomics.com/wp-content/uploads/2025/09/ep2-snorna-sdrna-scarna.png?w=1024)
snoRNA, sdRNA, scaRNA [How many types of ncRNA do you know? Ep. 2/7]
This week, our journey in the ncRNAs universe brings us into the very heart of the cell, in its nucleus! With a view on the cytoplasm… Let’s get going fellow travellers! 4. small nucleolar RNA (snoRNA) They are ~60-300 nt in length, and are derived from the introns of both protein-coding and non-protein-coding genes. They…
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![rRNA, tRNA, tsRNA [How many types of ncRNA do you know? Ep. 1/7]](https://writingenomics.com/wp-content/uploads/2025/08/ep1-trna-rrna-tsrna.png?w=1024)
rRNA, tRNA, tsRNA [How many types of ncRNA do you know? Ep. 1/7]
Welcome to the universe of non-coding RNAs! This is a gigantic realm – our cells transcribe over 75% of the genome into RNAs that are never translated! [1, 2] – where the unknown is not just around the proverbial corner, but it often stares you straight in the eyes… Over the next few weeks, I’ll…
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How many types of non-coding RNA do you know?
Only 2% of the human genome codes for a protein [1], and yet 75% is transcribed [2]. These non-coding RNAs (ncRNAs) show a mind-boggling heterogeneity of sizes, shapes, origins and functions. Many ncRNAs are essential, either directing or fine-tuning cellular, and a few types are so poorly understood that they may even be junk. I…
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![The Central Dogma of Molecular Biology is not What You Think [Common Misconceptions in Genomics, EP. 3]](https://writingenomics.com/wp-content/uploads/2025/06/dre.png?w=1024)
The Central Dogma of Molecular Biology is not What You Think [Common Misconceptions in Genomics, EP. 3]
Like many of you, I believed I knew the Central Dogma of molecular biology: DNA→ RNA→Protein. I was wrong. Somewhat shocked, I learned what it really means only last week, after digging in a paper older than my dad – I am a sucker for the history of science… Funnily enough, textbooks are probably responsible…
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